Figure 1.
Flowchart of compound screen.
Figure 2.
Mice were infected with T. cruzi (1×104) on day 0 and treated with the drugs (n = 6 per group) from day 7 to 11. Doses of drugs are shown in Table 5. Bloodstream trypomastigotes were quantified at the indicated time points. Mortality is plotted in the lower panels. Mice were euthanized when they showed high parasitemia and weights dropped below 20% of baseline.
Figure 3.
As in figure 2.
Table 1.
Compounds excluded from further study.
Table 2.
Categories of 151 hit compounds.*
Table 3.
In vitro activity of compounds selected for synergy testing.
Table 4.
Sum of FICs.
Table 5.
Doses of drugs used in mouse experiments, given once per day (except where indicated in Figures) for 5 consecutive days by oral gavage.