Table 1.
Clinical and biological characteristics of Curachik patients*.
Figure 1.
Clinical features of ambulatory CHIKV+ve patients* at days 1, 7 and 25.
These clinical data were collected from three consultations with a general practitioner on day 1, day 7 (mean 6.4, SD = 1.4) and day 25 (mean 26.5, SD = 9.8) of the disease during the Reunion island outbreak 2005–2006. * Since clinical assessment during the first medical visit was obtained prior to the beginning of the treatment, all CHIKV+ve patients (N = 54) could be used for analysis. By contrast, only patients who received the placebo (N = 27) were included in the study of disease evolution (second and third medical visits).
Figure 2.
Quality of life assessed by ambulatory CHIKV+ve patients* from day 1 until day 14.
Three kind of quality of life (health status, capacity to perform normal activity and quality of sleep) were assessed by self reported visual analogic scale (VAS) from “very bad” (VAS = 0) to “very good” (VAS = 100) and are represented here by box plot diagrams. Box plot is a representative diagram of continuous variables. The bottom and the top of the box are the 25th and 75th percentile, the band near the middle is the median and the ends of the whiskers are the 1.5 inter-quartile of the lower and upper quartile. The data not included between the whiskers are plotted as an outlier with small circles (if between 1.5 to 3 inter-quartile of the lower or upper quartile) or with a star (if higher than 3 inter-quartile of the lower or upper quartile). The outliers are tagged with their patient numbers to follow them at different time period. * Clinical assessment at D1 was obtained from all CHIKV+ve patients (N = 54) during the Reunion island outbreak 2005–2006. Only patients receiving placebo (N = 27) were included in D2–D14 clinical assessment.
Figure 3.
Number and intensity of arthralgic joints for CHIKV+ve* patients.
Figure 3A: Self reported number of arthralgic joints reported per person (day 1–day 14). Figure 3B: Percentage of patients with absent, minimal, moderate or severe arthralgia (day 1–day 14). * Characteristics of patients included and details of box plots are the same as reported in figure 2.
Figure 4.
Clinical and clinico-biological score for the diagnosis of CHIK.
These scores were based on patients who reported fever and arthralgia for less than 48 hours. * MCP+: arthralgia on at least one metacarpophalangeal joint. * W+: arthralgia on at least one wrist. We propose a clinical score based exclusively on clinical data (W+, MCP+ and Myalgia absent or minor) and a clinico-biological score that further includes lymphopenia (<1G/L). The result of the score represents the predicted probability to have chikungunya (see calculation of scores in the main text).
Table 2.
Intra-host genetic diversity analysis of CHIKV populations deciphered from 10 sera of CHIKV+ve patients.