Table 1.
Sensitivity of rK39 RDT and CLA ELISA in samples from infected and uninfected dogs.
Figure 1.
rK39 ELISA results in Brazilian dogs that tested positive or negative by rK39 RDT.
rK39 ELISA results expressed as signal/positive (s/p) ratio. Dashed line indicates the rK39 ELISA cut-off.
Figure 2.
Sensitivity of CLA ELISA and rK39 RDT, and the proportion of symptomatic dogs, through time.
Samples (n = 285) were aligned by time from first detection of infection. Key: CLA ELISA (open circles); rK39 RDT (closed circles); symptomatics (triangles). Each point represents 15–50 dogs.
Figure 3.
Proportion of dogs positive by rK39 RDT according to anti-CLA IgG concentrations.
IgG concentrations expressed as arbitrary units/mL relative to positive control serum, by ELISA. Each point represents 31–32 samples. Dashed line indicates the CLA ELISA cut-off.
Figure 4.
Proportion of infected dogs positive by CLA ELISA and rK39 RDT according to parasite density in bone marrow.
Parasite density expressed as number of parasites/mL of bone marrow biopsy by quantitative kDNA PCR. Key: CLA ELISA (open circles); rK39 RDT (closed circles). Each point represents 25 samples.
Table 2.
Factors associated with a positive rK39 RDT result in samples from infected Brazilian dogs.
Figure 5.
Flow diagram for study inclusion in meta-analysis.
Table 3.
Estimates of the sensitivity of rK39 RDTs to detect symptomatic visceral leishmaniasis in dogs.
Table 4.
Estimates of the sensitivity of rK39 RDTs to detect asymptomatic Leishmania infantum infection in dogs.
Table 5.
Estimates of the sensitivity of rK39 RDTs to detect Leishmania infantum infection in dogs.
Table 6.
Estimates of the specificity of rK39 RDTs in dogs.
Table 7.
Specificity of rK39 RDTs in various groups of control dogs.