Table 1.
Characteristics of the Study Population.
Figure 1.
Prevalence of intestinal helminths.
The prevalence of Trichuris trichiura eggs (TTE), Ascaris lumbricoides eggs (ALE), Hookworm eggs (HWE) and Strongyloides stercoralis larvae (SSL) was assessed in stools from children enrolled in the longitudinal cohort during the first 5 years of life.
Table 2.
Summary of results (n = 142).
Figure 2.
Representative antibody profiles.
Antibody responses to Wb123, Bm14, BM33 and WSP were monitored in serum samples for child #5331 (panel A) and child #2604 (panel B). collected over time. First detection of antigenemia (by Og4C3 ELISA) and microfilaremia are indicated. Microfilaremic children were treated with DEC.
Figure 3.
Age prevalence of microfilaremia, antigenemia and antifilarial antibody responses.
Circulating filarial antigen and microfilaria prevalence are shown in the top panel A. Antibody responses to Bm14, Bm33, Wb123, and WSP filarial antigens are shown in the bottom panel B.
Table 3.
Seroconversion rates by antigen.
Table 4.
Antibody response by infection status.
Figure 4.
Quantitative changes in antibody among antigen-positive children.
Shown are Bm33 (panel A), Bm14 (panel B), and Wb123 (panel C) antibody levels by age for antigen-positive children. In this plot, boxes represent the 25th–5th percentile with the line in the box, the median. Whiskers represent the10th and 90th percentile and filled circles are 5th and 95th percentile. Note that Luminex unit values are specific to each antigen and should not be assumed to be equivalent across antigens.
Figure 5.
Quantitative changes in antibody among antigen-negative children.
Shown are Bm33 (panel A), Bm14 (panel B), and Wb123 (panel C) antibody levels by age for antigen-negative children. In this plot, boxes represent the 25th–5th percentile with the line in the box, the median. Whiskers represent the10th and 90th percentile and filled circles are 5th and 95th percentile.
Table 5.
Cox proportional hazards model for initial Bm14 antibody response.