Table 1.
Patient population.
Figure 1.
Prevalences of Ab to Wb123, CAg, and Mf in 1975 and 1992.
Percent prevalence (y-axis) of microfilaremia (Mf; grey bars), circulating antigen (CAg; blue bars), and Ab to Wb123 (red bars) by age group (x-axis) for the study population on Mauke in 1975 (left panel) and 1992 (right panel). Asterisks represent a significant difference (p≤0.004; Fisher's exact test) between Wb123 Ab prevelances in 1975 and 1992 within a given age group.
Figure 2.
Prevalence of Ab to Wb123 in CAg− individuals.
Percent prevalence (y-axis) of Ab to Wb123 by age group (x-axis) in CAg− individuals on Mauke from 1975 (red line) and 1992 (blue line). Asterisks represent a significant difference (p≤0.04; Fisher's exact test) between the prevelances in 1975 and 1992 within a given age group.
Figure 3.
Levels of Ab to Wb123 by CAg Status in 1975 and 1992.
Ab levels to Wb123 segregated by CAg status in subjects from 1975 (left side) and 1992 (right side). Each dot represents an individual patient, and the black bars represent the geometric means. The dashed line represents the lower limit of the assay (10,968 units) and p-values were calculated using the Mann-Whitney U test.
Figure 4.
Levels of Ab to Wb123 in Patients Seen in Both 1975 and 1992.
Change in the production of Ab to Wb123 as measured by LIPS in individuals seen in both 1975 (red dots) and 1992 (blue dots) segregated by CAg status. Each line represents an individual patient (n = 28 [CAg+ to CAg+]; n = 40 [CAg+ to CAg−]; n = 46 [CAg− to CAg−]); asterisks represent the geometric means for each group. The dashed line in each graph represents the upper limit of the normal level (10,968 units) of the LIPS assay and p-values were calculated using the Wilcoxon Signed Rank test.
Figure 5.
Prevalence of Ab to Wb123 in Young Children.
Prevalence of Ab to Wb123 (i.e. the percent positive for Ab) in children ≤5 years old in 1975. The red bar for children <1 year presumably indicates the presence of maternal Ab.
Figure 6.
Prevalence of Ab to Wb123 in Children from 1975 and 1992.
Prevalence of Ab to Wb123 (i.e. the percent positive for Ab) in children ≤11 years old by 2 year age divisions in 1975 (left panel; red bars) and 1992 (right panel; blue bars). The shaded green area represents the period of time where children were born after island-wide treatment with DEC. Asterisks indicate a significant difference (p≤0.0045) by Fisher's Exact test between identical age groups from both time periods.
Figure 7.
Levels of Ab to Wb123 in Children from 1975 and 1992.
Ab levels to Wb123 in children ≤11 years old by 2 year age divisions in 1975 (red dots) and 1992 (blue dots). Each dot represents a single individual and the black bars represent the geometric means for each group. The shaded grey area indicates values considered negative and p-values were calculated using the Mann Whitney U test.