Figure 1.
Patient with borderline tuberculoid leprosy face lesion with severe Type 1 Reaction.
Facial patch in severe Type1 Reaction with erythema and oedema of the lesion and mild scaling.
Table 1.
Ridley-Jopling classification, Bacterial Index and Granuloma Fraction for skin biopsies.
Figure 2.
Skin borderline tuberculoid leprosy in Type 1 Reaction.
Skin - BT in Type 1 Reaction showing aggressive epithelioid granuloma, epidermal erosion, extracellular oedema and lymphocytic influx. H&E staining ×20.
Figure 3.
Delayed-type hypersensitivity in dermal nerve.
Skin - BT in Type 1 Reaction showing aggressive DTH with epithelioid granuloma destroying a deep dermal nerve, areas of necrosis and focal lymphocytic response. H&E staining ×20.
Table 2.
Classification of patients by Ridley-Jopling and reaction types.
Table 3.
Immuno-staining in skin biopsies for CD68, TNF-α, TGF-β and iNOS.*
Figure 4.
Skin showing CD68 positive macrophages. IHC staining ×40.
Figure 5.
Skin showing TGF-β positive macrophages. IHC staining ×100.
Table 4.
Histological classification of nerve biopsies.
Table 5.
Comparison of Bacterial Index in skin and nerve biopsies.
Figure 6.
Nerve showing CD68 positive macrophages. IHC staining ×40.
Table 6.
Immuno-staining in nerve biopsies for CD68, TNF-α, TGF-β and iNOS.*
Figure 7.
Nerve showing TNF-α positive macrophages. ICH staining ×40.
Figure 8.
Nerve showing TGF-β positive macrophages. IHC staining ×100.
Figure 9.
Nerve showing S100 positive areas of staining of intact fibers and areas of absence of stain in segments of nerve destruction. IHC staining ×20.