Figure 1.
*All L.loa positive patients were additionally assigned to this group (numbers and dropouts provided in italics).
Table 1.
Characteristics of patient groups that completed the trial (enrolment, treatment allocations and all follow ups).
Table 2.
incidence and severity of adverse events during doxycycline and following ivermectin treatment.
Figure 2.
Changes in Onchocerca volvulus microfilaridermia from baseline at 4 months, 12 months and 21 months post treatment with doxycycline + ivermectin, doxycycline only or ivermectin only.
Arrows indicate commencement of intervention (black arrow; doxycycline, red arrow; ivermectin).
Table 3.
Changes in O. volvulus microfilaridermia at 4, 12 and 21 months after the start of treatment.
Figure 3.
Immunohistochemical assessment of Wolbachia and nematode viability within adult O. volvulus tissue derived from trial patients at 21 months after the start of treatment.
A: WSP-specific immunostaining (arrow) of Wolbachia in O. volvulus adult female after ivermectin only treatment, B: Lack of WSP staining in O. volvulus from a doxycycline + ivermectin treated individual. C: APR staining (arrow) of viable adult female O. volvulus after ivermectin only treatment. D: Lack of APR staining in a non-viable adult worm from a doxycycline treated individual.
Table 4.
Changes in Wolbachia surface protein expression and wsp DNA copy number in onchocercomas 21 months following start of treatment.
Table 5.
Histological analysis of embryonic stages within uteri and released mf in onchocercoma tissue.
Table 6.
Analysis of USG detection of adult O. volvulus worm movement 21 months after the start of treatment.
Table 7.
O. volvulus viability 21 months after the start of treatment.
Figure 4.
Changes in Loa loa microfilaridermia from baseline at 4 months, 12 months and 21 months post treatment with doxycycline + ivermectin, doxycycline only or ivermectin only.
Arrows indicate commencement of intervention (black arrow; doxycycline, red arrow; ivermectin).
Table 8.
Changes in L. loa parasitaemia at 4, 12 and 21 months after the start of treatment.
Figure 5.
Changes in Mansonella perstans microfilaridermia from baseline at 4 months, 12 months and 21 months post treatment with doxycycline + ivermectin, doxycycline only or ivermectin only.
Arrows indicate commencement of intervention (black arrow; doxycycline, red arrow; ivermectin).
Table 9.
Changes in M. perstans parasitaemia at 4, 12 and 21 months after the start of treatment.