Table 1.
Temporal and geographic distribution of T. b. rhodesiense isolates and clones.
Figure 1.
Parasitaemia curves generated by four T.b. rhodesiense cloned strains after experimental fly (Glossina pallidipes) infection of nine vervet monkeys (+-476, □-515, ♦-536, ◊-523, ▪-579, ▴-556, x-574, •-554, ▵-555).
After a variable pre-patent period, the parasitaemia tended to plateau but with more clearly defined waves of relapse and recrudescence in the individuals with longer disease duration.
Table 2.
Evolution of clinical parameters of vervet monkeys that were infected with T. b. rhodesiense cloned strains through tsetse (Glossina pallidipes) transmission.
Table 3.
Progressive changes in haematology indices of vervet monkeys infected with T.b. rhodesiense cloned strains through cyclic (tsetse; Glossina pallidipes) transmission.
Figure 2.
Changes in the mean corpuscular volume (MCV) mean corpuscular haemoglobin (MCH) and Red cell distribution width (RDW) in two vervet monkeys (•-554 and ▵-555) that were infected with T.b. rhodesiense KETRI 3928.
Panel A: MCV; Panel B: MCH; and Panel C: RDW. Note that while both MCV and MCH decreased below pre-infection levels and remained low throughout; RDW increased throughout the infection.
Figure 3.
Changes in total and differential white blood cell numbers in vervet 554 that was infected with T.b. rhodesiense KETRI 3928.
During the early part of the infection, granulocytes and lymphocytes are approximately equal while later in the infection, lymphocytes are clearly the predominant cell type. (X- Total WBC, ▴-lymphocytes, ▵-Granulocytes, ▪-Monocytes).
Table 4.
Blood white cell changes in vervet monkeys infected with T.b. rhodesiense cloned strains through cyclic (tsetse; Glossina pallidipes) transmission.
Figure 4.
Changes in cerebrospinal fluid (CSF) trypanosomes (▪) and white cell (▴) during the course of infection of vervet 476 with T.b. rhodesiense KETRI 3741.
Phase 1: early stage infection; Phase 2: transition of intermediate stage infection and phase 3: late stage disease which at terminal point was marked by surge in trypanosome numbers and white cell counts.