Protective and therapeutic effects of Lactobacillus brevis PQ214320 and Bacillus subtilis PQ198038 Against experimental Trichinella Infection
Fig 6
Representative histopathological photomicrographs of diaphragm muscle in the different experimental mice groups (n = 5).
C: Positive Trichinella untreated control mice showing multiple T. spiralis larvae (black arrow) associated with a severe inflammatory cell infiltrate (green arrow), and congestion of blood vessels (BV) (H&E, low × 200 and high ×400 Magnifications). ALB: Infected mice treated with Albendazole, ALB group displaying damaged T. spiralis larvae (black arrow) associated with moderate infiltration of inflammatory cells (green arrow) (H&E, low × 200 and high ×400 Magnifications). BS: Infected mice post-treated with B. subtilis PQ198038, BS group exhibiting some T. spiralis larvae (black arrow) associated with a mild inflammatory cell aggregation (green arrow) (H&E, low × 200 and high ×400 Magnifications). BSP: Infected mice pre-treated with B. subtilis PQ198038, before infection and continued after infection, BSP group displaying a small number of T. spiralis larvae (black arrow) associated with a mild inflammatory cellular infiltration (green arrow), and congested blood vessels (BV) (H&E, low × 200 and high ×400 Magnifications). L: Infected mice post-treated with L. brevis PQ214320, 19 days after infection, L group showing a small number of T. spiralis larvae (black arrow) associated with a mild aggregation of inflammatory cells (green arrow) (H&E, low × 200 and high ×400 Magnifications). LP: Infected mice pre-treated with L. brevis PQ214320, before infection and continued to 19 days after infection, LP group exhibiting a noticeable improvement without any larvae (Star), with minimal aggregation of inflammatory cells (arrow) (H&E, low × 200 and high ×400 Magnifications).