Intestinal Lactobacillus johnsonii protects against neuroangiostrongyliasis in BALB/c mice through modulation of immune response
Fig 2
Angiostrongylus cantonensis infection induces changes in the gut microbiome.
(A-C) Alpha diversity of the microbiomes in uninfected and infected mice. (A) qPCR-based quantification of total 16S copy-number in 1 ng of stool DNA, as shown by Ct values per ng DNA. (B) Chao index, for estimation of the number of OTUs per sample. (C) Shannon index, for estimation of the microbial diversity in each sample. (D) Principal co-ordinates analysis (PCoA) based on Bray-Curtis distance on the mice’s microbiomes between uninfected and infected mice. The x and y axes represent the first, second, and third principal coordinates. The value in percentage in the axis label represents the contribution of the corresponding coordinate to the sample variance. (E-G) Taxa summary of bacterial phyla (E), class (F), and genera (G; showing only the top 32 most abundant classifications) from uninfected and infected mice. n = 6 mice in each group. Data in (A-C) are presented as mean ± S.D. A.U., arbitrary unit. Significance determined by unpaired T-test, with p < 0.05 considered significant.