Transcriptional phenotype of the anti-parasitic benzodiazepine meclonazepam on the blood fluke Schistosoma mansoni
Fig 5
Potential mechanisms of meclonazepam and praziquantel.
MCLZ and PZQ have nearly identical phenotypes on adult parasites (left), such as contractile paralysis and tegument damage, as well as similar transcriptional responses. Both compounds are agonists at heterologously expressed, homomeric TRP channels (right); MCLZ on Smp_333650 (purple) and PZQ on Smp_246790 (blue) [18,19]. Within the parasite, these TRP subunits could conceivably form either homomeric or heteromeric channels consisting of multiple subunits expressed in the same cell type. Analysis of single cell transcriptomic data [35] (bottom) for Smp_333650 and Smp_246790. Muscle clusters 1 - 8 are ordered left to right, as are neuron clusters 1 - 31. Dot diameter denotes the percentage of cells within the cell type cluster expressing the gene of interest. Dot color indicates the average expression of the indicated gene by cluster.