The evolutionary and molecular history of a chikungunya virus outbreak lineage
Fig 4
Emergent mutations in the Nsp3, 6K and CP proteins.
All mutations were mapped onto the ColabFold-predicted structural models. Positions of mutations are shown as purple sticks, and the overall colouring of the proteins is according to the pLDDT score indicating the confidence of the prediction. Blue colour signifies highest prediction confidence and orange lowest as shown by the legend. A) Emergent mutations in Nsp3 protein. Macro and Zinc-binding domains are indicated. B) Predicted structure of 6K protein with highlighted V6I mutation. C) Capsid protein model with highlighted mutations in the disordered N-terminal tail of the protein. D) Summary of all emergent mutations found in the Nsp3, 6K and capsid proteins.