The evolutionary and molecular history of a chikungunya virus outbreak lineage
Fig 3
Emergent mutations in the E1-E2-E3 spike complex.
A) Representative view of the Spike trimer. Structural models for visualization were obtained from PDBid 6jo8 [47]. E1 is coloured cyan, E2 blue and E3 is green. The receptor Mxra8 is included to aid the visualization of the receptor binding interface and is coloured brown. The position of the membrane at the base of the spike is indicated. All emergent mutations are shown as sticks and coloured purple as in Fig 2. B) Close-up view, highlighting the mutations on E1. The domains I, II and III are indicated. C) enlarged model of E2 highlighting emergent mutations. Domains A, B and C are indicated. D) Close-up view, showcasing the mutations on E3. E) Summary of all mutations found in the spike complex. Asterix denotes mutations that are not part of the analysed structure and are therefore not visualized.