JQ-1 ameliorates schistosomiasis liver granuloma in mice by suppressing male and female reproductive systems and egg development of Schistosoma japonicum
Fig 6
Effect of JQ-1 treatment on liver granuloma in mice infected with S. japonicum.
(A) Protocol used to assess liver granuloma in mice. (B) Gross appearance of livers obtained from mice infected with S. japonicum and treated with JQ-1 or vehicle (HP-β-CD). Liver slices stained with hematoxylin and eosin. Scale bars: 500 μm. (C) Measurement of granuloma area as a percentage of total area as assessed by computer-aided morphometry. (D) Liver weights of S. japonicum infected mice treated with JQ-1 or HP-β-CD. (E) Spleen weights of S. japonicum infected mice treated with JQ-1 or HP-β-CD. (F) Effect of JQ-1 treatment on serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in mice infected with S. japonicum. (G) Effect of JQ-1 treatment on mRNA expression of inflammation-related genes in the liver of mice infected with S. japonicum. Data represent the mean ± SEM (n = 9 for each group). Asterisks denote statistically significant differences (Student’s t-test, *P < 0.05; **P < 0.01) vs. the HP-β-CD–treated control group.