JQ-1 ameliorates schistosomiasis liver granuloma in mice by suppressing male and female reproductive systems and egg development of Schistosoma japonicum
Fig 2
Effect of JQ-1 on cell proliferation in male-female pairs of S. japonicum.
Red signals indicate active mitotic cells labeled by EdU; blue signals, Hoechst-positive cells. (A-D) Male S. japonicum and (E-H) female S. japonicum. EdU-incorporated cells are detected in the testes and parenchyma of untreated males (A) and in the vitellarium and ovary of untreated females (E). EdU-positive cells are detected after application of JQ-1 at 5 μM (B, F), 10 μM (C, G), and 15 μM (D, H). Abbreviations: ov, ovary; t, testes; SV, seminal vesicles. Scale bars: 200 μm.