Intrageneric cross-reactivity of monospecific rabbit antisera against venoms of the medically most important Bitis spp. and Echis spp. African snakes
Fig 5
Cross-neutralization of toxic activities of Bitis spp. venoms by monospecific antisera.
Cross-neutralization of A) lethal and B) hemorrhagic activities of Bitis spp. venoms. Only the antisera that gave higher than 33% cross-reactivity by ELISA were tested in these assays. Neutralization is expressed as ED50, i.e., mg venom neutralized per mL antivenom. In the case of lethality, error bars represent the 95% confidence intervals, while in the case of hemorrhage, error bars represent SD (n = 4). *Non-overlapping values with the anti-lethal 95% CI of the homologous serum, or no detectable ability to neutralize the hemorrhagic activity. ↓ heterologous sera that were no tested as they have less than 33% content of specific antibodies of the corresponding homologous serum.