Factors associated with variation in single-dose albendazole pharmacokinetics: A systematic review and modelling analysis
Fig 3
Albendazole sulfoxide pharmacokinetic variability, stratified by patient and dosage features.
In all panels displayed above, each pale line represents the fitted model output for a single time-series, with the darker lines representing the average of the time-series for a given category. Factors explored were (A) Sex; (B) Feeding Status (according to whether groups had received the single dose of albendazole alongside a fatty meal or not); (C) Dose (with time-series crudely categorised into high/low strata based on whether the dose was higher or lower than 400 mg); (D) Infection Status (defined, following the article associated with each time-series, as whether the patient group were receiving treatment for a known infection or not); (E) Co-Administered Drugs (i.e. whether albendazole was delivered alone or in tandem with other drugs); and (F) Age Group, defined as to whether the average age of the patients was under 18 years (children) or ≥18 years (adults).