Factors associated with variation in single-dose albendazole pharmacokinetics: A systematic review and modelling analysis
Fig 2
Schematic representation of the model describing albendazole and albendazole sulfoxide pharmacokinetics.
A compartmental model consisting of a series of linked ordinary differential equations (ODEs) was developed to simulate the pharmacokinetics of albendazole and its pharmacodynamically-active metabolite, albendazole sulfoxide, in plasma following a single oral dose. (A) Schematic representation illustrating the model structure and the way in which the different compartments are linked. (B) Overview of the ODEs governing the model, representing the amount of albendazole in the gut (G) and concentration of the drug (or its metabolite albendazole sulfoxide) in the liver (L) and systemic circulation, plasma (P). The received dose is further scaled by a systemic availability parameter not shown here (see Text B in S1 File for further details and full description of the model equations).