Antibody response to a new member of the DBL family (EBP2) after a brief Plasmodium vivax exposure
Fig 5
IgG response to distinct P.vivax DBL vaccine candidates among individuals with different previous malaria episodes.
Frequency and levels of IgG antibody against P. vivax (A) EBP2 and (B) DEKnull-2 among (1) Outbreak (n = 55)—individuals from non-endemic region, including recurrent P. vivax infection (closed circle) and without recurrence (open circle) and, individuals long-term malaria exposure from endemic region with (2) Single previous malaria episode (n = 20) and multiple episodes (n = 49). Sera reactivity was expressed as ELISA Reactivity Index (RI). Samples with RI > 1.0 were considered positive. The percentage (%) of positive IgG antibody response to each protein was expressed at the top of the graph. Differences statistically significant were indicate by asterisk (*P<0.05, ** P<0.01, *** P<0.001, **** P<0.0001).