Antibody response to a new member of the DBL family (EBP2) after a brief Plasmodium vivax exposure
Fig 2
IgM and IgG antibodies responses to P. vivax antigens after the first P. vivax exposure.
(A) Frequency and level of IgM antibodies against P. vivax EBP2, DEKnull-2 and MSP1-19 in individuals with acute P. vivax infection (Case, n = 16), and relatives and/ or neighbors without malaria symptoms (non-Case, n = 22). (B) Frequency and level of IgG antibody against P. vivax EBP2, DEKnull-2 and MSP1-19 in Case and non-Case. The IgM and IgG antibody responses were evaluated at the outbreak (BL, baseline), 3, 6 and 12 months after the P. vivax outbreak for Case group, and at BL, 3, 6-month for non-Case group. Sera reactivity was expressed as ELISA Reactivity Index (RI). Percentage (%) of antigen-specific IgM and IgG positive was expressed at the top of the graph. The dashed line represents RI = 1. Samples with RI > 1.0 are considered positive. Differences statistically significant were indicate by asterisk (*P<0.05, ** P<0.01, *** P<0.001, **** P<0.0001).