Pulmonary haemorrhage as the earliest sign of severe leptospirosis in hamster model challenged with Leptospira interrogans strain HP358
Fig 5
Histopathological lesions in kidneys of infected hamsters.
Congestion occurred as early as day 3 p.i., haemorrhage, infiltration of inflammatory cells, dilation and collapse of Bowman’s space on day 4 p.i. and dilation of tubule and degeneration of epithelial cells in proximal and distal tubules occurred on day 5 p.i. onwards. CG: Congested glomerulus, CB: Collapse of Bowman’s space, DB: Dilated Bowman’s space, DT: Dilated tubule, DPD: Degeneration of epithelial cells in proximal and distal tubules, IC: Infiltration of inflammatory cells, and H: Haemorrhage. C: Control, D1-D7: Day 1- day 7 and DD: Dead. Magnification: x100, bar: 100 μm.