Berbamine hydrochloride potently inhibits SARS-CoV-2 infection by blocking S protein-mediated membrane fusion
Fig 5
Generated the binding mode of berbamine hydrochloride in the post fusion core of SARS-CoV-2 S2 subunit.
The 3D structure of berbamine hydrochloride and proteins were obtained from ZINC (ID: ZINC38139356) and PDB (ID: 6LXT) databases, respectively. The interaction sites between berbamine hydrochloride and S2 were predicted by Autodock vina algorithm. The SARS-CoV-2 S2 residues involved in berbamine hydrochloride binding are shown as green sticks.