Drug metabolism and pharmacokinetics of praziquantel: A review of variable drug exposure during schistosomiasis treatment in human hosts and experimental models
Fig 6
Each bar represents the percentage change in AUC during the drug combination in comparison to PZQ alone. The effect of the drug combination is listed above the bar chart, with ±20% representing the boundaries of no effect due to interindividual variation [87]. The data were extracted from five papers [54, 59, 84–86], compiled in S10 Table, analysed to create percentage change in AUC and then plotted to aid further analysis. ABZ, albendazole; AUC, area under the curve; BIC, bicarbonate; CHQ, chloroquine; CIM, cimetidine; DDI, drug–drug interaction; GLUC, glucose; KTZ, ketoconazole; PZQ, praziquantel.