Drug metabolism and pharmacokinetics of praziquantel: A review of variable drug exposure during schistosomiasis treatment in human hosts and experimental models
Fig 5
The DDIs identified by the review, and the resultant effect on PZQ exposure.
The in vivo model and “Drug B” are listed as well as the overall effect of the drug combination on exposure of PZQ. The effect of the drug combination on PZQ efficacy in rodents was calculated based on the percentage change in WBR of each drug alone in comparison to the combined action (S9 Table) [73–83]. The effect of the drug combination on PZQ efficacy in humans was calculated based on the percentage change in AUC of each drug alone in comparison to the combined action (S10 Table) [54, 59, 84–86]. AUC, area under the curve; DDI, drug–drug interaction; PZQ, praziquantel; WBR, worm burden reduction.