Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis
Fig 6
Time dependent disappearance of the Pol I Expression Site Body (ESB) in T. brucei incubated with Pol I transcription inhibitors.
Quantitation of ESB presence in T. brucei cells in the G1 cell cycle stage incubated with various concentrations of quarfloxin (A), BMH-21 (B), CX-5461 (C) or 800 nM suramin (D). The percentage (%) of cells with an ESB after incubation for the time indicated in hours (h) is shown. A total of 100 cells (two biological replicates of ~50 cells) was analysed with the standard deviation indicated with error bars.