Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis
Fig 2
Pol I transcription inhibitors kill bloodstream form Trypanosoma brucei in a time and dose dependent manner.
Cell proliferation assays were performed in which T. brucei SM cells were exposed to a range of concentrations of Pol I inhibitors including quarfloxin (A), BMH-21 (B) or CX-5461 (C) using the anti-trypanosomal agent suramin (D) as a control. The graph shows the cell density of treated parasites in comparison with the untreated T. brucei SM line at 0, 16, 24, 40 and 48 hours. The mean of four biological replicate experiments for the Pol I inhibitors, or three replicates for the suramin control are shown with standard deviation indicated with error bars.