Role of T3SS-1 SipD Protein in Protecting Mice against Non-typhoidal Salmonella Typhimurium
Fig 5
Protective efficacy of PrgI and SipD (A-D).
Mice (N = 14–16) were immunized at days 0, 21 and 42 or 0, 21, 42 and 63 by the indicated routes. Six weeks after the last immunization: at day 84 for the SC (A), IN (B) and OG 3I (C) routes; at day 105 for the OG 4I (D) route, 106 CFU/mL (100 LD 50) of S. Typhimurium were administered orally to immunized and control mice. Survival was monitored for 21 days. Statistical significance was determined using a 2-tailed Fisher's exact test. Statistically significant differences are indicated by *** p < 0.001, ** 0.001<p <0.01 and * p< 0.05 compared to PBS groups.