Low Protective Efficacy of the Current Japanese Encephalitis Vaccine against the Emerging Genotype 5 Japanese Encephalitis Virus
Fig 3
SA14-14-2 JE LAV–induced immune response in two-year-old children 28 days before and after vaccination.
PRNT90 titers against viral strains of different JEV genotypes are shown before and 28 days after a vaccination: (A) G1 JEV (GZ56 strain), (B) G3 JEV (P3 strain) and (C) G5 JEV (XZ0934 strain). (D) end-point PRNT90 titers against three genotypes JEV antibodies were assayed. The gray lines indicate PRNT90 titer = 1:10. PRNT90 titers of ≥1:10 were considered protective. The seroconversion rates (SCRs) and geometric mean titers (GMTs) are given in each panel. P < 0.05 showed statistically significant.