Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases—Not Glycolipid Processing Enzymes
Fig 1
Iminosugars used in this study.
Iminosugars are sugar mimics with nitrogen substitution of the endocyclic oxygen. Sugars from which iminosugars are derived are presented to the left with d-glucose on top (white background) and d-galactose on the bottom (grey background). A lead clinical candidate for DENV antiviral activity, celgosivir, is a pro-drug of castanospermine, both of which possess d-glucose stereochemistry. A series of deoxynojirimycin (DNJ) derivatives with variable alkylation of the ring nitrogen was synthesized for comparison to equivalent galactose mimic deoxygalactonojirimycin (DGJ) derivatives.