Vaccination with Replication Deficient Adenovectors Encoding YF-17D Antigens Induces Long-Lasting Protection from Severe Yellow Fever Virus Infection in Mice
Fig 5
Viral loads in the brains of mice vaccinated with Ad-YF NS3 or Ad-YF NS3 (201–325) reflect CD8+ T cell numbers.
Non-vaccinated, Ad-YF NS3 vaccinated or Ad-YF NS3 (201–325) vaccinated WT B6 mice (filled squares) as well as Ad-YF NS3 vaccinated H-2Kb KO mice (open squares) were challenged with YFV intracranial 14 after vaccination, and viral titers in the CNS were determined 7 days later. Symbols denote individual animals.