Chemotherapy of Second Stage Human African Trypanosomiasis: Comparison between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys
Fig 5
Primary and relapse parasitaemia in infected vervet monkeys treated with the diamidine prodrug DB868.
DB868 was administered orally at (A) 20 mg/kg/day, (B) 10 mg/kg/day, or (C) 3 mg/kg/day for 10 consecutive days following infection with T. b. rhodesiense KETRI 2537 (28–37 days post-infection); the monkeys were confirmed to have progressed to second stage HAT before initiation of treatment. Relapse infections occurred at different times in specific individuals. Relapsed monkeys were rescue-treated with melarsoprol administered intravenously at 3.6 mg/kg/day for 4 consecutive days. F, female; M, male.