An Adult Mouse Model of Vibrio cholerae-induced Diarrhea for Studying Pathogenesis and Potential Therapy of Cholera
Figure 3
Effect of CFTRinh-172 on V. cholerae-induced intestinal fluid secretion in adult mice.
After inoculation of V. cholerae into ileal loops, 20 µg of CFTRinh-172 was administered into mouse peritoneal cavity every 6 h. At 12 h after V. cholerae challenge, ileal loops were removed for measurement of loop weight/length ratio. (A) Representative photographs of ileal loops after indicated treatments. (B) Loop weight/length ratio with indicated treatments. Data were expressed as mean ± S.E. (n = 4). ***, P<0.01 compared with V. cholerae-inoculated control.