Hyaluronidase of Bloodsucking Insects and Its Enhancing Effect on Leishmania Infection in Mice
Figure 6
Effect of hyaluronidase on Leishmania infection in mice.
BALB/c mice were coinoculated intradermally into ear with 104 or 105 Leishmania major and hyaluronidase equivalent to 0, 2 and 10 salivary glands of Phlebotomus papatasi. Lesion size, given as a product of its area (mm2) and the degree of ulceration (1–5), was monitored for 6 weeks post infection. Points (▪) = mean values, boxes = 95% confidence intervals, whiskers = min-max values. The p values of corresponding Kruskal-Wallis ANOVA are provided.