Development of Highly Organized Lymphoid Structures in Buruli Ulcer Lesions after Treatment with Rifampicin and Streptomycin
Figure 1
Histopathological characteristics associated with untreated Buruli ulcer lesions.
Histological sections of specimen from untreated Buruli ulcer lesions stained with HE (A to D) and ZN (E, F), respectively. Photographs are taken at magnification ×40 (A, B, E), ×100 (C, D) or ×1000 (F). (A) Vasculitis associated minor leukocyte infiltration around vessels with intact dermal connective tissue and epidermal hyperplasia. (B) Extensive areas of necrosis in the deeper dermis and large fat cell ghosts with slight leukocyte infiltrates. (C) Slight cellular infiltration mainly composed of PMNL. (D) Ongoing necrotic/apoptotic processes surrounding a focus of mycobacterial microcolonies. (E) Typical clusters of extracellular bacteria between adipose cell ghosts. (F) Sometimes also single bacilli can be spotted inside necrotic regions.