A clinical scoring system for the early identification of superinfections in patients with severe fever with thrombocytopenia syndrome: An ambispective multicentre cohort study

Yu-Yao Li; Jian-Kang Zhang; Chun Zhang; Zhi-Ping Pan; Xiao Liu; Meng-Yu Liu; Qiang Chen; Yuan-Yuan Zhang; Yuan Jiang; Xu-Ya Yuan; Si-Yang Liu; Xiang Li; Fei-Dan Yu; Yu-Feng Gao; Jun Cheng; Qin-Xiu Xie; Jian-Guo Rao; Li-Yu Zhu; Zhen-Jun Liu; Ying Ye; Jia-Bin Li; Li-Fen Hu

doi:10.1371/journal.pntd.0014696

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Open Access

Peer-reviewed

Research Article

A clinical scoring system for the early identification of superinfections in patients with severe fever with thrombocytopenia syndrome: An ambispective multicentre cohort study

Yu-Yao Li ,

Contributed equally to this work with: Yu-Yao Li, Jian-Kang Zhang, Chun Zhang, Zhi-Ping Pan

Roles Conceptualization, Formal analysis, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
⨯
Jian-Kang Zhang ,

Contributed equally to this work with: Yu-Yao Li, Jian-Kang Zhang, Chun Zhang, Zhi-Ping Pan

Roles Data curation, Investigation

Affiliation Department of Infectious Diseases, Lu’an People’s Hospital, Lu’an, Anhui, China
⨯
Chun Zhang ,

Contributed equally to this work with: Yu-Yao Li, Jian-Kang Zhang, Chun Zhang, Zhi-Ping Pan

Roles Data curation, Investigation

Affiliations Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China, Department of Infectious Diseases, Chaohu Hospital of Anhui Medical University, Chaohu, Anhui, China
⨯
Zhi-Ping Pan ,

Contributed equally to this work with: Yu-Yao Li, Jian-Kang Zhang, Chun Zhang, Zhi-Ping Pan

Roles Data curation, Investigation

Affiliations Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China, Department of Infectious Diseases, Anqing Municipal Hospital, Anqing, Anhui, China
⨯
Xiao Liu ,

Roles Formal analysis, Methodology, Validation

¶‡ These authors are senior authors on this work.

Affiliation Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
⨯
Meng-Yu Liu,

Roles Investigation

Affiliation Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
⨯
Qiang Chen,

Roles Investigation

Affiliation Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
⨯
Yuan-Yuan Zhang,

Roles Investigation

Affiliation Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
⨯
Yuan Jiang,

Roles Investigation

Affiliation Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
⨯
Xu-Ya Yuan,

Roles Investigation

Affiliation Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
⨯
Si-Yang Liu,

Roles Investigation

Affiliation Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
⨯
Xiang Li,

Roles Investigation

Affiliation Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
⨯
Fei-Dan Yu,

Roles Investigation

Affiliations Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China, Anhui Province Key Laboratory of Infectious Diseases, Anhui Medical University, Hefei, China
⨯
Yu-Feng Gao,

Roles Data curation

Affiliations Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China, Anhui Province Key Laboratory of Infectious Diseases, Anhui Medical University, Hefei, China
⨯
Jun Cheng,

Roles Data curation

Affiliations Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China, Anhui Province Key Laboratory of Infectious Diseases, Anhui Medical University, Hefei, China
⨯
Qin-Xiu Xie,

Roles Data curation

Affiliations Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China, Anhui Province Key Laboratory of Infectious Diseases, Anhui Medical University, Hefei, China
⨯
Jian-Guo Rao,

Roles Data curation

Affiliation Department of Infectious Diseases, Lu’an People’s Hospital, Lu’an, Anhui, China
⨯
Li-Yu Zhu,

Roles Data curation

Affiliation Department of Infectious Diseases, Chaohu Hospital of Anhui Medical University, Chaohu, Anhui, China
⨯
Zhen-Jun Liu,

Roles Data curation

Affiliation Department of Infectious Diseases, Anqing Municipal Hospital, Anqing, Anhui, China
⨯
Ying Ye ,

Roles Conceptualization

* E-mail: hulifen@ahmu.edu.cn (L-FH); lijiabin@ahmu.edu.cn (J-BL); yeying2@139.com (YY)

Affiliations Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China, Anhui Province Key Laboratory of Infectious Diseases, Anhui Medical University, Hefei, China
⨯
Jia-Bin Li ,

Roles Conceptualization, Funding acquisition

* E-mail: hulifen@ahmu.edu.cn (L-FH); lijiabin@ahmu.edu.cn (J-BL); yeying2@139.com (YY)

Affiliations Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China, Anhui Province Key Laboratory of Infectious Diseases, Anhui Medical University, Hefei, China, Department of Infectious Diseases, Public Health Clinical Center of Anhui Province, Hefei, China
⨯
[ ... ],
Li-Fen Hu

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: hulifen@ahmu.edu.cn (L-FH); lijiabin@ahmu.edu.cn (J-BL); yeying2@139.com (YY)

Affiliations Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China, Anhui Province Key Laboratory of Infectious Diseases, Anhui Medical University, Hefei, China, Department of Infectious Diseases, Public Health Clinical Center of Anhui Province, Hefei, China, Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore, Singapore

https://orcid.org/0000-0002-9782-8802

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A clinical scoring system for the early identification of superinfections in patients with severe fever with thrombocytopenia syndrome: An ambispective multicentre cohort study

Yu-Yao Li,
Jian-Kang Zhang,
Chun Zhang,
Zhi-Ping Pan,
Xiao Liu,
Meng-Yu Liu,
Qiang Chen,
Yuan-Yuan Zhang,
Yuan Jiang,
Xu-Ya Yuan

Published: September 10, 2026
https://doi.org/10.1371/journal.pntd.0014696

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