Prioritization of chemical scaffolds using the TDR Targets database: An integrative workflow for Trypanosoma cruzi drug discovery

Lionel Urán Landaburu; Mercedes Didier Garnham; Emir Salas Sarduy; Fernán Agüero

doi:10.1371/journal.pntd.0014648

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Peer-reviewed

Research Article

Prioritization of chemical scaffolds using the TDR Targets database: An integrative workflow for Trypanosoma cruzi drug discovery

Lionel Urán Landaburu ,

Contributed equally to this work with: Lionel Urán Landaburu, Mercedes Didier Garnham

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

Affiliations Escuela de Bio y Nanotecnologías (EByN), Universidad Nacional de San Martín (UNSAM), San Martín, Buenos Aires, Argentina, Instituto de Investigaciones Biotecnológicas (IIBIO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), San Martín, Buenos Aires, Argentina
⨯
Mercedes Didier Garnham ,

Contributed equally to this work with: Lionel Urán Landaburu, Mercedes Didier Garnham

Roles Data curation, Funding acquisition, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Escuela de Bio y Nanotecnologías (EByN), Universidad Nacional de San Martín (UNSAM), San Martín, Buenos Aires, Argentina, Instituto de Investigaciones Biotecnológicas (IIBIO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), San Martín, Buenos Aires, Argentina
⨯
Emir Salas Sarduy,

Roles Data curation, Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliations Escuela de Bio y Nanotecnologías (EByN), Universidad Nacional de San Martín (UNSAM), San Martín, Buenos Aires, Argentina, Instituto de Investigaciones Biotecnológicas (IIBIO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), San Martín, Buenos Aires, Argentina
⨯
Fernán Agüero

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: fernan@iib.unsam.edu.ar

Affiliations Escuela de Bio y Nanotecnologías (EByN), Universidad Nacional de San Martín (UNSAM), San Martín, Buenos Aires, Argentina, Instituto de Investigaciones Biotecnológicas (IIBIO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), San Martín, Buenos Aires, Argentina

https://orcid.org/0000-0003-1331-5741

⨯

Prioritization of chemical scaffolds using the TDR Targets database: An integrative workflow for Trypanosoma cruzi drug discovery

Lionel Urán Landaburu,
Mercedes Didier Garnham,
Emir Salas Sarduy,
Fernán Agüero

Published: August 24, 2026
https://doi.org/10.1371/journal.pntd.0014648

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