Brucella outer membrane protein 16 induces trophoblast pyroptosis via rewiring IL-6 trans-signaling and caspase-3/GSDME axis

• Hui Ren ,

  Contributed equally to this work with: Hui Ren, Guanti Lai, Wenjie Shen

  Roles Data curation, Project administration, Writing – original draft

  Affiliations Department of Transfusion Medicine, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China, Institute of Blood Transfusion and Hematology, Guangzhou Blood Center, Guangzhou Medical University, Guangzhou, China, The Key Medical Laboratory of Guangzhou, Guangzhou, China

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• Guanti Lai ,

  Contributed equally to this work with: Hui Ren, Guanti Lai, Wenjie Shen

  Roles Data curation, Software

  Affiliation Department of Transfusion Medicine, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China

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• Wenjie Shen ,

  Contributed equally to this work with: Hui Ren, Guanti Lai, Wenjie Shen

  Roles Data curation, Resources

  Affiliation Senior Department of Obstetrics and Gynecology, The Seventh Medical Center of PLA General Hospital, Beijing, China

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• Tianhang Zhu,

  Roles Software

  Affiliation Department of Urinary Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China

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• Heng Yang,

  Roles Data curation, Investigation, Methodology, Software

  Affiliations Department of Transfusion Medicine, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China, Department of Transfusion Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China

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• Yongshui Fu,

  Roles Formal analysis, Investigation, Methodology

  Affiliations Department of Transfusion Medicine, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China, Institute of Blood Transfusion and Hematology, Guangzhou Blood Center, Guangzhou Medical University, Guangzhou, China, The Key Medical Laboratory of Guangzhou, Guangzhou, China, Guangzhou First People’s Hospital, Guangzhou, China

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• Chengyao Li,

  Roles Resources

  Affiliation Department of Transfusion Medicine, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China

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• Tingting Li,

  Roles Resources

  Affiliations Department of Transfusion Medicine, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China, Department of Transfusion Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China

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• Hailong Su ,

  Roles Conceptualization, Supervision, Writing – original draft

  * E-mail: wenjing@smu.edu.cn (WW); yzdxshl@126.com (HS)

  Affiliations Department of Transfusion Medicine, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China, Department of Immunology, Zunyi Medical University, Zunyi, China, Key Laboratory for Cancer Prevention and treatment of Guizhou Province, Zunyi, China

  https://orcid.org/0000-0002-5091-4033

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• Wenjing Wang

  Roles Conceptualization, Project administration, Supervision

  * E-mail: wenjing@smu.edu.cn (WW); yzdxshl@126.com (HS)

  Affiliations Department of Transfusion Medicine, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China, Department of Transfusion Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China

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