CD163⁺ monocytes and soluble CD163 as prognostic indicators in severe fever with thrombocytopenia syndrome: An integrative analysis

Jie Wang; Haolin Song; Yi Zhang; Ziling Cheng; Lingtong Huang; Bei Jia; Guangqi Zhu; Lifen Hu; Jihua Xue; Jie Li; Wei Wu; Qi Xia

doi:10.1371/journal.pntd.0014416

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Open Access

Peer-reviewed

Research Article

CD163⁺ monocytes and soluble CD163 as prognostic indicators in severe fever with thrombocytopenia syndrome: An integrative analysis

Jie Wang ,

Contributed equally to this work with: Jie Wang, Haolin Song, Yi Zhang

Roles Writing – original draft, Writing – review & editing

Affiliation State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Haolin Song ,

Contributed equally to this work with: Jie Wang, Haolin Song, Yi Zhang

Roles Data curation, Formal analysis, Writing – original draft

Affiliation State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Yi Zhang ,

Contributed equally to this work with: Jie Wang, Haolin Song, Yi Zhang

Roles Data curation

Affiliation Department of Laboratory Medicine, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Ziling Cheng,

Roles Data curation

Affiliation State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Lingtong Huang,

Roles Data curation

Affiliation Department of Critical Care Units, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Bei Jia,

Roles Data curation

Affiliation Department of Infectious Diseases, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
⨯
Guangqi Zhu,

Roles Data curation

Affiliation Department of Infectious Diseases, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
⨯
Lifen Hu,

Roles Data curation

Affiliation Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
⨯
Jihua Xue,

Roles Data curation

Affiliation Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
⨯
Jie Li ,

Roles Writing – review & editing

* E-mail: xiaqi@zju.edu.cn (QX), zjuwuwei@zju.edu.cn (WW), Lijier@nju.edu.cn (JL)

Affiliation Department of Infectious Diseases, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
⨯
Wei Wu ,

Roles Conceptualization, Formal analysis, Writing – review & editing

* E-mail: xiaqi@zju.edu.cn (QX), zjuwuwei@zju.edu.cn (WW), Lijier@nju.edu.cn (JL)

Affiliation State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

https://orcid.org/0000-0003-2892-5956

⨯
Qi Xia

Roles Conceptualization

* E-mail: xiaqi@zju.edu.cn (QX), zjuwuwei@zju.edu.cn (WW), Lijier@nju.edu.cn (JL)

Affiliation State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯

CD163⁺ monocytes and soluble CD163 as prognostic indicators in severe fever with thrombocytopenia syndrome: An integrative analysis

Jie Wang,
Haolin Song,
Yi Zhang,
Ziling Cheng,
Lingtong Huang,
Bei Jia,
Guangqi Zhu,
Lifen Hu,
Jihua Xue,
Jie Li

Published: June 3, 2026
https://doi.org/10.1371/journal.pntd.0014416

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