Dual role of Japanese encephalitis virus fusion loop peptide antibodies in Zika virus infection

Kexin Xi; Xuenan Zhang; Jingshu Li; Yuqi Zhao; Xiaoting Xie; Chenguang Shen; Bao Zhang; Li Zhu; Weiwei Xiao; Chengsong Wan; Yifan Lin; Linqing Wang; Yingfang Liu; Yuyan Wang; Jianhai Yu; Qinghua Wu; Wei Zhao

doi:10.1371/journal.pntd.0014296

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Open Access

Peer-reviewed

Research Article

Dual role of Japanese encephalitis virus fusion loop peptide antibodies in Zika virus infection

Kexin Xi ,

Contributed equally to this work with: Kexin Xi, Xuenan Zhang, Jingshu Li, Yuqi Zhao

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

Current Address: School of Public Health, Southern Medical University, Baiyun District, Guangzhou, Guangdong Province, China.

Affiliation Department of Biosafety Level 3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China
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Xuenan Zhang ,

Contributed equally to this work with: Kexin Xi, Xuenan Zhang, Jingshu Li, Yuqi Zhao

Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Current Address: School of Public Health, Southern Medical University, Baiyun District, Guangzhou, Guangdong Province, China.

Affiliation Department of Biosafety Level 3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China
⨯
Jingshu Li ,

Contributed equally to this work with: Kexin Xi, Xuenan Zhang, Jingshu Li, Yuqi Zhao

Roles Data curation, Methodology, Visualization

Current Address: School of Public Health, Southern Medical University, Baiyun District, Guangzhou, Guangdong Province, China.

Affiliation Department of Biosafety Level 3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China
⨯
Yuqi Zhao ,

Contributed equally to this work with: Kexin Xi, Xuenan Zhang, Jingshu Li, Yuqi Zhao

Roles Data curation, Methodology, Visualization

Current Address: School of Public Health, Southern Medical University, Baiyun District, Guangzhou, Guangdong Province, China.

Affiliation Department of Biosafety Level 3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China
⨯
Xiaoting Xie,

Roles Data curation, Formal analysis, Methodology, Visualization

Current Address: School of Public Health, Southern Medical University, Baiyun District, Guangzhou, Guangdong Province, China.

Affiliation Department of Biosafety Level 3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China
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Chenguang Shen,

Roles Supervision

Current Address: School of Public Health, Southern Medical University, Baiyun District, Guangzhou, Guangdong Province, China.

Affiliation Department of Biosafety Level 3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China
⨯
Bao Zhang,

Roles Supervision

Current Address: School of Public Health, Southern Medical University, Baiyun District, Guangzhou, Guangdong Province, China.

Affiliation Department of Biosafety Level 3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China
⨯
Li Zhu,

Roles Supervision

Current Address: School of Public Health, Southern Medical University, Baiyun District, Guangzhou, Guangdong Province, China.

Affiliation Department of Biosafety Level 3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China
⨯
Weiwei Xiao,

Roles Supervision

Current Address: School of Public Health, Southern Medical University, Baiyun District, Guangzhou, Guangdong Province, China.

Affiliation Department of Biosafety Level 3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China
⨯
Chengsong Wan,

Roles Supervision

Current Address: School of Public Health, Southern Medical University, Baiyun District, Guangzhou, Guangdong Province, China.

Affiliation Department of Biosafety Level 3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China
⨯
Yifan Lin,

Roles Investigation

Current Address: School of Public Health, Southern Medical University, Baiyun District, Guangzhou, Guangdong Province, China.

Affiliation Department of Biosafety Level 3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China
⨯
Linqing Wang,

Roles Investigation

Current Address: School of Public Health, Southern Medical University, Baiyun District, Guangzhou, Guangdong Province, China.

Affiliation Department of Biosafety Level 3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China
⨯
Yingfang Liu,

Roles Investigation

Current Address: School of Public Health, Southern Medical University, Baiyun District, Guangzhou, Guangdong Province, China.

Affiliation Department of Biosafety Level 3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China
⨯
Yuyan Wang ,

Roles Supervision

* E-mail: 308391675@qq.com (YW); chienhai@163.com (JY); wuqh@smu.edu.cn (QW); zhaowei@smu.edu.cn (WZ)

Current Address: Nanfang Hospital, Southern Medical University, Baiyun District, Guangzhou, Guangdong Province, China.

Affiliation Department of Geriatrics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China
⨯
Jianhai Yu ,

Roles Conceptualization, Project administration, Resources, Supervision

* E-mail: 308391675@qq.com (YW); chienhai@163.com (JY); wuqh@smu.edu.cn (QW); zhaowei@smu.edu.cn (WZ)

Current Address: School of Public Health, Southern Medical University, Baiyun District, Guangzhou, Guangdong Province, China.

Affiliation Department of Biosafety Level 3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China
⨯
Qinghua Wu ,

Roles Supervision

* E-mail: 308391675@qq.com (YW); chienhai@163.com (JY); wuqh@smu.edu.cn (QW); zhaowei@smu.edu.cn (WZ)

Current Address: School of Public Health, Southern Medical University, Baiyun District, Guangzhou, Guangdong Province, China.

Affiliation Department of Biosafety Level 3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China
⨯
[ ... ],
Wei Zhao

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: 308391675@qq.com (YW); chienhai@163.com (JY); wuqh@smu.edu.cn (QW); zhaowei@smu.edu.cn (WZ)

Current Address: School of Public Health, Southern Medical University, Baiyun District, Guangzhou, Guangdong Province, China.

Affiliation Department of Biosafety Level 3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China

https://orcid.org/0000-0003-1414-4438

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Dual role of Japanese encephalitis virus fusion loop peptide antibodies in Zika virus infection

Kexin Xi,
Xuenan Zhang,
Jingshu Li,
Yuqi Zhao,
Xiaoting Xie,
Chenguang Shen,
Bao Zhang,
Li Zhu,
Weiwei Xiao,
Chengsong Wan

Published: May 4, 2026
https://doi.org/10.1371/journal.pntd.0014296

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