Functional single nucleotide polymorphisms in CACNA2D3 and other autophagy-related genes are associated with leprosy among Brazilians

• Isabela Espasandin ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: isabela.espasandin@gmail.com

  Affiliation Leprosy Laboratory, Oswaldo Cruz Institute/FIOCRUZ, Rio de Janeiro, Rio de Janeiro, Brazil

  https://orcid.org/0009-0005-4251-9550

  ⨯
• Cynthia Chester Cardoso,

  Roles Formal analysis, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Molecular Virology Laboratory, Department of Genetics, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil

  ⨯
• Thyago Leal-Calvo,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation University of California Berkeley, Innovative Genomics Institute, Berkeley, California, United States of America

  ⨯
• Mayara Abud Mendes,

  Roles Methodology

  Affiliation Leprosy Laboratory, Oswaldo Cruz Institute/FIOCRUZ, Rio de Janeiro, Rio de Janeiro, Brazil

  ⨯
• Ana Carla Pereira Latini,

  Roles Methodology

  Affiliation Research and Teaching Division, Lauro de Souza Lima Institute, Bauru, São Paulo, Brazil

  ⨯
• Samuel Henrique Malcher de Castro,

  Roles Formal analysis, Methodology

  Affiliation Laboratory of Molecular Biology, Alfredo da Matta Hospital Foundation, Manaus, Amazonas, Brazil

  ⨯
• André Luiz Leturiondo,

  Roles Methodology, Writing – review & editing

  Affiliation Laboratory of Molecular Biology, Alfredo da Matta Hospital Foundation, Manaus, Amazonas, Brazil

  ⨯
• Ohanna Cavalcanti de Lima Bezerra,

  Roles Methodology, Writing – review & editing

  Affiliation Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada

  ⨯
• Roberta Olmo Pinheiro,

  Roles Funding acquisition, Methodology, Project administration, Resources, Writing – review & editing

  Affiliation Leprosy Laboratory, Oswaldo Cruz Institute/FIOCRUZ, Rio de Janeiro, Rio de Janeiro, Brazil

  ⨯
• Anna Maria Sales,

  Roles Data curation, Methodology

  Affiliation Leprosy Laboratory, Oswaldo Cruz Institute/FIOCRUZ, Rio de Janeiro, Rio de Janeiro, Brazil

  ⨯
• Milton Ozório Moraes ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  ¶☯ These authors contributed equally to this work and are sharing the last authorship.

  ¶† Deceased.

  Affiliation Leprosy Laboratory, Oswaldo Cruz Institute/FIOCRUZ, Rio de Janeiro, Rio de Janeiro, Brazil

  ⨯
• Fernanda de Souza Gomes Kehdy

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Software, Supervision, Visualization, Writing – review & editing

  ¶☯ These authors contributed equally to this work and are sharing the last authorship.

  Affiliation Leprosy Laboratory, Oswaldo Cruz Institute/FIOCRUZ, Rio de Janeiro, Rio de Janeiro, Brazil

  ⨯