A functional crosstalk between circulating follicular helper 2 T cells and memory B cells drives anti-Plasmodium vivax antibodies

Zulfa Zahra Salsabila; Piyawan Kochayoo; Tipanan Khunsri; Pachara Tianpothong; Chaniya Leepiyasakulchai; Pongsakorn Thawornpan; Julius Clemence R. Hafalla; John H. Adams; Patchanee Chootong

doi:10.1371/journal.pntd.0014232

Loading metrics

Open Access

Peer-reviewed

Research Article

A functional crosstalk between circulating follicular helper 2 T cells and memory B cells drives anti-Plasmodium vivax antibodies

Zulfa Zahra Salsabila,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand
⨯
Piyawan Kochayoo,

Roles Formal analysis

Affiliation Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand
⨯
Tipanan Khunsri,

Roles Formal analysis

Affiliation Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand
⨯
Pachara Tianpothong,

Roles Formal analysis

Affiliation Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand
⨯
Chaniya Leepiyasakulchai,

Roles Formal analysis

Affiliation Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand
⨯
Pongsakorn Thawornpan,

Roles Formal analysis

Affiliation Department of Community Medical Technology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand
⨯
Julius Clemence R. Hafalla,

Roles Formal analysis

Affiliation Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
John H. Adams,

Roles Resources

Affiliation Center for Global Health and Inter-Disciplinary Research, College of Public Health, University of South Florida, Tampa, Florida, United States of America
⨯
Patchanee Chootong

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: pchooton@gmail.com

Affiliation Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand

https://orcid.org/0000-0001-6892-4494

⨯

A functional crosstalk between circulating follicular helper 2 T cells and memory B cells drives anti-Plasmodium vivax antibodies

Zulfa Zahra Salsabila,
Piyawan Kochayoo,
Tipanan Khunsri,
Pachara Tianpothong,
Chaniya Leepiyasakulchai,
Pongsakorn Thawornpan,
Julius Clemence R. Hafalla,
John H. Adams,
Patchanee Chootong

Published: April 24, 2026
https://doi.org/10.1371/journal.pntd.0014232

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Antibodies
Is the Subject Area "Antibodies" applicable to this article?

Thanks for your feedback.
Plasmodium
Is the Subject Area "Plasmodium" applicable to this article?

Thanks for your feedback.
Malaria
Is the Subject Area "Malaria" applicable to this article?

Thanks for your feedback.
Antibody production
Is the Subject Area "Antibody production" applicable to this article?

Thanks for your feedback.
Antibody response
Is the Subject Area "Antibody response" applicable to this article?

Thanks for your feedback.
Cell differentiation
Is the Subject Area "Cell differentiation" applicable to this article?

Thanks for your feedback.
B cells
Is the Subject Area "B cells" applicable to this article?

Thanks for your feedback.
Malarial parasites
Is the Subject Area "Malarial parasites" applicable to this article?

Thanks for your feedback.