The circadian clock gene CYCLE as a potential target for disrupting blood-feeding behavior in the mosquito Culex pipiens

Chanuka Wijewardana; Yunxuan Chen; Chenxuan Jiang; Yinghui Zhou; Yuhan Guo; Donghui Zhang; Lu Chen; Min Hou; Zhipeng Xu; Yaping Hu; MinJun Ji; Lin Chen

doi:10.1371/journal.pntd.0014218

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Open Access

Peer-reviewed

Research Article

The circadian clock gene CYCLE as a potential target for disrupting blood-feeding behavior in the mosquito Culex pipiens

Chanuka Wijewardana,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Department of Pathogen Biology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Yunxuan Chen,

Roles Data curation, Investigation, Methodology

Affiliation Department of Pathogen Biology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Chenxuan Jiang,

Roles Data curation, Methodology

Affiliation Department of Pathogen Biology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Yinghui Zhou,

Roles Formal analysis, Methodology

Affiliations Department of Pathogen Biology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China, Department of Clinical Laboratory, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Yuhan Guo,

Roles Formal analysis, Methodology

Affiliation Department of Pathogen Biology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Donghui Zhang,

Roles Formal analysis, Investigation

Affiliations Department of Pathogen Biology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China, Department of Teaching Management, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Lu Chen,

Roles Investigation, Methodology

Affiliations Department of Pathogen Biology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China, Key Laboratory for Infections and Control of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Min Hou,

Roles Methodology

Affiliations Department of Pathogen Biology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China, Key Laboratory for Infections and Control of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Zhipeng Xu,

Roles Methodology, Resources

Affiliations Department of Pathogen Biology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China, Key Laboratory for Infections and Control of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Yaping Hu ,

Roles Investigation, Resources, Validation

* E-mail: linchen@njmu.edu.cn (LC); jiminjun@njmu.edu.cn (MJ); huyap9009@163.com (YH)

Affiliation Scientific Observation and Research Station for Ecological Environment of Wuyi Mountains, Ministry of Ecology and Environment, China/Fujian Wuyishan State Integrated Monitoring Station for Ecological Quality of Forest Ecosystem/Nanjing Institute of Environmental Sciences, Ministry of Ecology and Environment, Nanjing, Jiangsu, China
⨯
MinJun Ji ,

Roles Resources, Validation

* E-mail: linchen@njmu.edu.cn (LC); jiminjun@njmu.edu.cn (MJ); huyap9009@163.com (YH)

Affiliations Department of Pathogen Biology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China, Key Laboratory for Infections and Control of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Lin Chen

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Supervision, Validation, Writing – review & editing

* E-mail: linchen@njmu.edu.cn (LC); jiminjun@njmu.edu.cn (MJ); huyap9009@163.com (YH)

Affiliations Department of Pathogen Biology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China, Key Laboratory for Infections and Control of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu, China

https://orcid.org/0000-0002-9876-0168

⨯

The circadian clock gene CYCLE as a potential target for disrupting blood-feeding behavior in the mosquito Culex pipiens

Chanuka Wijewardana,
Yunxuan Chen,
Chenxuan Jiang,
Yinghui Zhou,
Yuhan Guo,
Donghui Zhang,
Lu Chen,
Min Hou,
Zhipeng Xu,
Yaping Hu

Published: April 21, 2026
https://doi.org/10.1371/journal.pntd.0014218

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