Reduced cytochrome P-450 (CYP) 2D6 activity and Plasmodium vivax malaria risk in Amazonians: A retrospective, population-based cohort study

• Rodrigo M. Corder ,

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: rodrigo.corder@usp.br (RMC); muferrei@usp.br (MUF)

  Affiliations Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil, Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, London, United Kingdom, Global Health and Tropical Medicine (GHTM), Institute of Hygiene and Tropical Medicine, Nova University of Lisbon, Lisbon, Portugal

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• Maria Carolina S. B. Puça ,

  Contributed equally to this work with: Maria Carolina S. B. Puça

  Roles Conceptualization, Formal analysis, Investigation, Resources, Validation, Writing – original draft, Writing – review & editing

  Affiliations Molecular Biology and Malaria Immunology Research Group, René Rachou Institute, Fiocruz, Belo Horizonte, Brazil, Department of Microbiology, Tumour and Cell Biology, Karolinska Institute, Solna, Sweden

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• Carlos A. Prete,

  Roles Data curation, Formal analysis, Investigation, Software, Validation, Writing – original draft, Writing – review & editing

  Affiliations Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil, Department of Communications, School of Electrical and Computer Engineering, State University of Campinas, Campinas, Brazil

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• Winni A. Ladeia,

  Roles Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

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• Priscila T. Rodrigues,

  Roles Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing

  Affiliations Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil, Brazilian Biorenewables National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas, Brazil

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• Igor C. Johansen,

  Roles Data curation, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliations Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil, Department of Demography, Institute of Philosophy and Humanities, State University of Campinas, Campinas, Brazil

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• Tais Nobrega de Sousa ,

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Software, Supervision, Validation, Writing – original draft, Writing – review & editing

  ¶‡ Contributed equally as joint senior authors.

  Affiliations Molecular Biology and Malaria Immunology Research Group, René Rachou Institute, Fiocruz, Belo Horizonte, Brazil, Department of Microbiology, Tumour and Cell Biology, Karolinska Institute, Solna, Sweden

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• Marcelo U. Ferreira ,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: rodrigo.corder@usp.br (RMC); muferrei@usp.br (MUF)

  Affiliations Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil, Global Health and Tropical Medicine (GHTM), Institute of Hygiene and Tropical Medicine, Nova University of Lisbon, Lisbon, Portugal

  https://orcid.org/0000-0002-5293-9090

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• on behalf of the Mâncio Lima Cohort Study Working Group

  ¶Membership of the Mâncio Lima Cohort Study Working Group is listed in the Acknowledgments.

  Affiliation Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

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