Acod1/itaconate axis controls anxiety-like behaviors induced by chronic infection of Toxoplasma gondii in mice

• Ziyi Yan ,

  Contributed equally to this work with: Ziyi Yan, Yumeng Zhou, Yingting Huang, Huiling Lv

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliations Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, Jiangsu International Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, Jiangsu, China,, The First Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China, National Experimental Demonstration Center for Basic Medicine Education, Xuzhou Medical University, Xuzhou, Jiangsu, China

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• Yumeng Zhou ,

  Contributed equally to this work with: Ziyi Yan, Yumeng Zhou, Yingting Huang, Huiling Lv

  Roles Investigation, Writing – review & editing

  Affiliations Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, Jiangsu International Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, Jiangsu, China,, National Experimental Demonstration Center for Basic Medicine Education, Xuzhou Medical University, Xuzhou, Jiangsu, China, The Second Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China

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• Yingting Huang ,

  Contributed equally to this work with: Ziyi Yan, Yumeng Zhou, Yingting Huang, Huiling Lv

  Roles Investigation, Writing – review & editing

  Affiliations Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, Jiangsu International Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, Jiangsu, China,, National Experimental Demonstration Center for Basic Medicine Education, Xuzhou Medical University, Xuzhou, Jiangsu, China, The Second Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China

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• Huiling Lv ,

  Contributed equally to this work with: Ziyi Yan, Yumeng Zhou, Yingting Huang, Huiling Lv

  Roles Data curation, Investigation, Validation, Visualization, Writing – review & editing

  Affiliation Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, Jiangsu International Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, Jiangsu, China,

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• Siyu Li,

  Affiliations Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, Jiangsu International Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, Jiangsu, China,, National Experimental Demonstration Center for Basic Medicine Education, Xuzhou Medical University, Xuzhou, Jiangsu, China, The Second Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China

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• Yifan Zhang,

  Roles Visualization, Writing – review & editing

  Affiliations Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, Jiangsu International Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, Jiangsu, China,, The First Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China, National Experimental Demonstration Center for Basic Medicine Education, Xuzhou Medical University, Xuzhou, Jiangsu, China

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• Yan He,

  Roles Investigation, Writing – review & editing

  Affiliations Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, Jiangsu International Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, Jiangsu, China,, The First Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China, National Experimental Demonstration Center for Basic Medicine Education, Xuzhou Medical University, Xuzhou, Jiangsu, China

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• Xinde Jiang,

  Roles Validation, Visualization, Writing – review & editing

  Affiliations Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, Jiangsu International Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, Jiangsu, China,, The First Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China, National Experimental Demonstration Center for Basic Medicine Education, Xuzhou Medical University, Xuzhou, Jiangsu, China

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• Heng Deng,

  Roles Validation, Visualization, Writing – review & editing

  Affiliations Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, Jiangsu International Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, Jiangsu, China,, The First Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China, National Experimental Demonstration Center for Basic Medicine Education, Xuzhou Medical University, Xuzhou, Jiangsu, China

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• Yujuan Shen ,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  * E-mail: shenyj@nipd.chinacdc.cn (YS); zhangyumei@bzmc.edu.cn (YZ); panwei525@126.com (WP); fen_1208@163.com (FS)

  Affiliation National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, Shanghai, China

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• Yumei Zhang ,

  Roles Conceptualization, Methodology, Resources, Supervision, Visualization, Writing – review & editing

  * E-mail: shenyj@nipd.chinacdc.cn (YS); zhangyumei@bzmc.edu.cn (YZ); panwei525@126.com (WP); fen_1208@163.com (FS)

  Affiliation Department of Pathogenic Biology, Binzhou Medical University, Yantai, Shandong, China

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• Wei Pan ,

  Roles Conceptualization, Funding acquisition, Resources, Writing – original draft, Writing – review & editing

  * E-mail: shenyj@nipd.chinacdc.cn (YS); zhangyumei@bzmc.edu.cn (YZ); panwei525@126.com (WP); fen_1208@163.com (FS)

  Affiliations Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, Jiangsu International Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, Jiangsu, China,, National Experimental Demonstration Center for Basic Medicine Education, Xuzhou Medical University, Xuzhou, Jiangsu, China

  https://orcid.org/0000-0003-2641-1759

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• Fenfen Sun

  Roles Conceptualization, Supervision, Writing – review & editing

  * E-mail: shenyj@nipd.chinacdc.cn (YS); zhangyumei@bzmc.edu.cn (YZ); panwei525@126.com (WP); fen_1208@163.com (FS)

  Affiliations Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, Jiangsu International Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, Jiangsu, China,, National Experimental Demonstration Center for Basic Medicine Education, Xuzhou Medical University, Xuzhou, Jiangsu, China

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