Giardia duodenalis MIF induces host intestinal damage via CD74 receptor mediated NLRP3 inflammasome activation

Mengge Chen; Jianhua Li; Xiaocen Wang; Zhenzhen Liu; Xu Zhang; Heng Yang; Xuancheng Zhang; Hongyu Wang; Hongyan Kang; Yanhui Yu; Pengtao Gong; Nan Zhang; Xin Li

doi:10.1371/journal.pntd.0013968

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Open Access

Peer-reviewed

Research Article

Giardia duodenalis MIF induces host intestinal damage via CD74 receptor mediated NLRP3 inflammasome activation

Mengge Chen ,

Contributed equally to this work with: Mengge Chen, Jianhua Li, Xiaocen Wang

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China
⨯
Jianhua Li ,

Contributed equally to this work with: Mengge Chen, Jianhua Li, Xiaocen Wang

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China
⨯
Xiaocen Wang ,

Contributed equally to this work with: Mengge Chen, Jianhua Li, Xiaocen Wang

Roles Data curation, Formal analysis, Methodology, Project administration, Supervision, Writing – review & editing

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China
⨯
Zhenzhen Liu,

Roles Investigation, Writing – review & editing

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China
⨯
Xu Zhang,

Roles Formal analysis, Methodology, Visualization, Writing – review & editing

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China
⨯
Heng Yang,

Roles Investigation, Writing – review & editing

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China
⨯
Xuancheng Zhang,

Roles Methodology, Writing – review & editing

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China
⨯
Hongyu Wang,

Roles Investigation, Writing – review & editing

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China
⨯
Hongyan Kang,

Roles Investigation, Writing – review & editing

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China
⨯
Yanhui Yu,

Roles Resources, Writing – review & editing

Affiliation Second Affiliated Hospital, Jilin University, Changchun, China
⨯
Pengtao Gong,

Roles Resources, Writing – review & editing

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China
⨯
Nan Zhang,

Roles Resources, Writing – review & editing

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China
⨯
Xin Li

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing

* E-mail: lixin2018@jlu.edu.cn

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China

https://orcid.org/0009-0001-1600-6007

⨯

Giardia duodenalis MIF induces host intestinal damage via CD74 receptor mediated NLRP3 inflammasome activation

Mengge Chen,
Jianhua Li,
Xiaocen Wang,
Zhenzhen Liu,
Xu Zhang,
Heng Yang,
Xuancheng Zhang,
Hongyu Wang,
Hongyan Kang,
Yanhui Yu

Published: February 2, 2026
https://doi.org/10.1371/journal.pntd.0013968

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