Effect of a gut commensal Lactobacillus strain Limosilactobacillus caviae JL20 on leptospiral whole-cell inactivated vaccine in hamsters

Shilei Zhang; Lianjie Ma; Qi Cao; Meijing Zhang; Guixin Yan; Wanqi Jiang; Xufeng Xie; Wenlong Zhang; Yongguo Cao

doi:10.1371/journal.pntd.0013951

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Open Access

Peer-reviewed

Research Article

Effect of a gut commensal Lactobacillus strain Limosilactobacillus caviae JL20 on leptospiral whole-cell inactivated vaccine in hamsters

Shilei Zhang,

Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliations State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, P.R. China, Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, P.R. China
⨯
Lianjie Ma,

Roles Data curation, Investigation, Methodology

Affiliations State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, P.R. China, Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, P.R. China
⨯
Qi Cao,

Roles Formal analysis, Visualization

Affiliations State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, P.R. China, Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, P.R. China
⨯
Meijing Zhang,

Roles Data curation, Methodology, Validation

Affiliations State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, P.R. China, Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, P.R. China
⨯
Guixin Yan,

Roles Data curation, Formal analysis, Investigation

Affiliations State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, P.R. China, Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, P.R. China
⨯
Wanqi Jiang,

Roles Validation

Affiliations State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, P.R. China, Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, P.R. China
⨯
Xufeng Xie,

Roles Funding acquisition, Investigation, Software, Validation

Affiliations State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, P.R. China, Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, P.R. China
⨯
Wenlong Zhang ,

Roles Funding acquisition, Methodology, Supervision, Writing – review & editing

* E-mail: zwenlong123@126.com (WZ); ygcao82@jlu.edu.cn (YC)

Affiliations State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, P.R. China, Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, P.R. China

https://orcid.org/0000-0002-6313-2241

⨯
Yongguo Cao

Roles Conceptualization, Funding acquisition, Resources, Supervision

* E-mail: zwenlong123@126.com (WZ); ygcao82@jlu.edu.cn (YC)

Affiliations State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, P.R. China, Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, P.R. China
⨯

Effect of a gut commensal Lactobacillus strain Limosilactobacillus caviae JL20 on leptospiral whole-cell inactivated vaccine in hamsters

Shilei Zhang,
Lianjie Ma,
Qi Cao,
Meijing Zhang,
Guixin Yan,
Wanqi Jiang,
Xufeng Xie,
Wenlong Zhang,
Yongguo Cao

Published: February 3, 2026
https://doi.org/10.1371/journal.pntd.0013951

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