Immune checkpoint TIM-3 defines hyperactivated NK cells and predicts fatal outcome in severe fever with thrombocytopenia syndrome

• Xiaohan Qian ,

  Contributed equally to this work with: Xiaohan Qian, Yi Zhang

  Roles Data curation, Writing – original draft

  Affiliation State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

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• Yi Zhang ,

  Contributed equally to this work with: Xiaohan Qian, Yi Zhang

  Roles Data curation, Resources, Writing – original draft

  Affiliation Department of Laboratory Medicine, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

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• Ziling Cheng,

  Roles Formal analysis, Resources

  Affiliation State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

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• Haolin Song,

  Roles Resources

  Affiliation State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

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• Lingtong Huang,

  Roles Resources

  Affiliation Department of Critical Care Units, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

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• Bei Jia,

  Roles Methodology

  Affiliation Department of Infectious Diseases, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China

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• Jie Li ,

  Roles Methodology, Project administration, Writing – review & editing

  * E-mail: Lijier@nju.edu.cn (JL); wangjie_lethe@zju.edu.cn (JW); zjuwuwei@zju.edu.cn (WW)

  Affiliation Department of Infectious Diseases, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China

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• Jie Wang ,

  Roles Conceptualization, Project administration, Writing – review & editing

  * E-mail: Lijier@nju.edu.cn (JL); wangjie_lethe@zju.edu.cn (JW); zjuwuwei@zju.edu.cn (WW)

  Affiliation State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

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• Wei Wu

  Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

  * E-mail: Lijier@nju.edu.cn (JL); wangjie_lethe@zju.edu.cn (JW); zjuwuwei@zju.edu.cn (WW)

  Affiliation State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

  https://orcid.org/0000-0003-2892-5956

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