Untargeted metabolomics for triaging of cytochrome b inhibitors during Chagas’ disease drug discovery

A. Kenneth MacLeod; Lindsay B. Tulloch; Michele Tinti; Darren Edwards; Susan Wyllie; Kevin D. Read

doi:10.1371/journal.pntd.0013917

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Open Access

Peer-reviewed

Research Article

Untargeted metabolomics for triaging of cytochrome b inhibitors during Chagas’ disease drug discovery

A. Kenneth MacLeod ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: k.a.z.macleod@dundee.ac.uk

Affiliation Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom

https://orcid.org/0000-0001-6328-1178

⨯
Lindsay B. Tulloch,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Writing – original draft, Writing – review & editing

Affiliation Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
Michele Tinti,

Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
Darren Edwards,

Roles Methodology, Resources, Software

Affiliation Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
Susan Wyllie,

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
Kevin D. Read

Roles Funding acquisition, Project administration, Resources, Supervision

Affiliation Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯

Untargeted metabolomics for triaging of cytochrome b inhibitors during Chagas’ disease drug discovery

A. Kenneth MacLeod,
Lindsay B. Tulloch,
Michele Tinti,
Darren Edwards,
Susan Wyllie,
Kevin D. Read

Published: January 20, 2026
https://doi.org/10.1371/journal.pntd.0013917

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