Development of monoclonal antibodies against E1 protein of Chikungunya virus

Kun Wen; Zhihong Zhou; Peipei Xu; Biao Di; Jialing Song; Cuilian Yang; Lili Zhan; Chongquan Zhao; Mei Xu; Jianpiao Cai; Shuofeng Yuan; Kelvin Kai-Wang To; Wenxi Feng; Jasper Fuk-Woo Chan; Hongwei Zhou; Yue Chen; Xixia Ding

doi:10.1371/journal.pntd.0013794

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Open Access

Peer-reviewed

Research Article

Development of monoclonal antibodies against E1 protein of Chikungunya virus

Kun Wen ,

Contributed equally to this work with: Kun Wen, Zhihong Zhou, Peipei Xu, Biao Di

Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

Affiliations GuangDong Engineering Technology Research Center of Rapid Detection for Pathogenic Microorganisms, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China, Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
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Zhihong Zhou ,

Contributed equally to this work with: Kun Wen, Zhihong Zhou, Peipei Xu, Biao Di

Roles Data curation, Investigation

Affiliations GuangDong Engineering Technology Research Center of Rapid Detection for Pathogenic Microorganisms, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China, Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
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Peipei Xu ,

Contributed equally to this work with: Kun Wen, Zhihong Zhou, Peipei Xu, Biao Di

Roles Methodology, Data curation

Affiliations GuangDong Engineering Technology Research Center of Rapid Detection for Pathogenic Microorganisms, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China, Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
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Biao Di ,

Contributed equally to this work with: Kun Wen, Zhihong Zhou, Peipei Xu, Biao Di

Roles Data curation, Formal analysis, Investigation, Resources

Affiliation Center for Disease Control and Prevention of Guangzhou, Guangdong, People’s Republic of China
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Jialing Song,

Roles Data curation, Investigation

Affiliations GuangDong Engineering Technology Research Center of Rapid Detection for Pathogenic Microorganisms, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China, Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
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Cuilian Yang,

Roles Data curation

Affiliation Department of Blood Transfusion, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
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Lili Zhan,

Roles Data curation

Affiliations GuangDong Engineering Technology Research Center of Rapid Detection for Pathogenic Microorganisms, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China, Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
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Chongquan Zhao,

Roles Resources

Affiliations GuangDong Engineering Technology Research Center of Rapid Detection for Pathogenic Microorganisms, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China, Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
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Mei Xu,

Roles Methodology

Affiliations GuangDong Engineering Technology Research Center of Rapid Detection for Pathogenic Microorganisms, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China, Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
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Jianpiao Cai,

Roles Investigation, Visualization

Affiliation State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, People’s Republic of China
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Shuofeng Yuan,

Roles Investigation, Formal analysis

Affiliations GuangDong Engineering Technology Research Center of Rapid Detection for Pathogenic Microorganisms, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China, Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China, State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, People’s Republic of China, Department of Infectious Diseases and Microbiology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, People’s Republic of China
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Kelvin Kai-Wang To,

Roles Writing – review & editing

Affiliations State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, People’s Republic of China, Department of Infectious Diseases and Microbiology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, People’s Republic of China, Department of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region, People’s Republic of China
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Wenxi Feng ,

Roles Data curation, Resources, Validation, Writing – review & editing

* E-mail: dingxixia@126.com (XD); redcellchen@163.com (YC); hzhou@smu.edu.cn (HZ); jfwchan@hku.hk (JFWC); 25760620@qq.com (WF)

Affiliation Shunde District Center for Disease Control and Prevention, Foshan city, People’s Republic of China
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Jasper Fuk-Woo Chan ,

Roles Funding acquisition, Supervision, Writing – review & editing

* E-mail: dingxixia@126.com (XD); redcellchen@163.com (YC); hzhou@smu.edu.cn (HZ); jfwchan@hku.hk (JFWC); 25760620@qq.com (WF)

Affiliations State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, People’s Republic of China, Department of Infectious Diseases and Microbiology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, People’s Republic of China, Department of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region, People’s Republic of China
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Hongwei Zhou ,

Roles Validation, Writing – review & editing

* E-mail: dingxixia@126.com (XD); redcellchen@163.com (YC); hzhou@smu.edu.cn (HZ); jfwchan@hku.hk (JFWC); 25760620@qq.com (WF)

Affiliations GuangDong Engineering Technology Research Center of Rapid Detection for Pathogenic Microorganisms, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China, Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
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Yue Chen ,

Roles Data curation, Funding acquisition, Investigation

* E-mail: dingxixia@126.com (XD); redcellchen@163.com (YC); hzhou@smu.edu.cn (HZ); jfwchan@hku.hk (JFWC); 25760620@qq.com (WF)

Affiliation Center for Disease Prevention and Control of Southern Theatre Command of PLA, Guangdong Arbovirus Diseases Emergency Technology Research Center, Guangzhou, People’s Republic of China
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[ ... ],
Xixia Ding

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: dingxixia@126.com (XD); redcellchen@163.com (YC); hzhou@smu.edu.cn (HZ); jfwchan@hku.hk (JFWC); 25760620@qq.com (WF)

Affiliations GuangDong Engineering Technology Research Center of Rapid Detection for Pathogenic Microorganisms, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China, Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China

https://orcid.org/0000-0002-5790-6810

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Development of monoclonal antibodies against E1 protein of Chikungunya virus

Kun Wen,
Zhihong Zhou,
Peipei Xu,
Biao Di,
Jialing Song,
Cuilian Yang,
Lili Zhan,
Chongquan Zhao,
Mei Xu,
Jianpiao Cai

Published: December 4, 2025
https://doi.org/10.1371/journal.pntd.0013794

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