Crimean-Congo hemorrhagic fever virus NSm protein inhibits the type I interferon signaling by binding to STAT2

Rokusuke Yoshikawa; Yasuteru Sakurai; Sayako Kondo; Mayuko Kimura; Jiro Yasuda

doi:10.1371/journal.pntd.0013695

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Open Access

Peer-reviewed

Research Article

Crimean-Congo hemorrhagic fever virus NSm protein inhibits the type I interferon signaling by binding to STAT2

Rokusuke Yoshikawa,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Emerging Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan, Department of Emerging Infectious Diseases, National Research Center for the Control and Prevention of Infectious Diseases (CCPID), Nagasaki University, Nagasaki, Japan
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Yasuteru Sakurai,

Roles Investigation

Affiliations Department of Emerging Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan, Department of Emerging Infectious Diseases, National Research Center for the Control and Prevention of Infectious Diseases (CCPID), Nagasaki University, Nagasaki, Japan, School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan
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Sayako Kondo,

Roles Investigation

Affiliation Department of Emerging Infectious Diseases, National Research Center for the Control and Prevention of Infectious Diseases (CCPID), Nagasaki University, Nagasaki, Japan
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Mayuko Kimura,

Roles Investigation

Affiliation Department of Emerging Infectious Diseases, National Research Center for the Control and Prevention of Infectious Diseases (CCPID), Nagasaki University, Nagasaki, Japan
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Jiro Yasuda

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Validation, Writing – review & editing

* E-mail: j-yasuda@nagasaki-u.ac.jp

Affiliations Department of Emerging Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan, Department of Emerging Infectious Diseases, National Research Center for the Control and Prevention of Infectious Diseases (CCPID), Nagasaki University, Nagasaki, Japan, School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan

https://orcid.org/0000-0001-9928-5621

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Crimean-Congo hemorrhagic fever virus NSm protein inhibits the type I interferon signaling by binding to STAT2

Rokusuke Yoshikawa,
Yasuteru Sakurai,
Sayako Kondo,
Mayuko Kimura,
Jiro Yasuda

Published: November 4, 2025
https://doi.org/10.1371/journal.pntd.0013695

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Plasmid construction
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Transfection
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Protein expression
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Endoplasmic reticulum
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Cell signaling
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Crimean-Congo hemorrhagic fever
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STAT signaling
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Signal inhibition
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